乔雪，博雅特聘教授，博士生导师
国家杰出青年科学基金获得者
本课题组长期招收研究助理、博士后、博士生及六年制硕士生，欢迎申请！
教育经历
2003/09–2009/07，北京大学，药学院（六年制），学士、硕士
2009/09–2012/07，北京大学，药学院天然药物学系，博士
工作经历
2012/08-2018/07，北京大学，药学院，讲师
2016/10-2018/04，英国John Innes Centre，访问学者/博士后
2018/08-2025/07，北京大学，药学院，副教授，助理教授
2025/08-2026/07，北京大学，药学院，长聘副教授
2026/08- ，北京大学，药学院，长聘教授 / 博雅特聘教授
教学课程
1.《生药学》及《生药学实验》，本科生必修课
2.《生药学专业英语》，研究生课程
3.《中药分析》，研究生课程
研究领域
1. 中药药效成分的合成生物学。
中药活性成分的生物合成途径解析；生物合成酶的发现、改造及催化机制；合成生物学。
2. 中药化学成分及体内代谢分析新方法。
中药化学成分分析、质量控制、体内代谢、功能代谢组学。
科研项目
1. 国家自然科学基金杰出青年科学基金，主持
2. 国家自然科学基金优秀青年科学基金，主持
3. 北京市自然科学基金杰出青年科学基金，主持
4. 国家重点研发计划，课题负责人
学术兼职
世界中医药学会联合会中药分析专业委员会 副会长
中华中医药学会中药鉴定分会 副主任委员
中华中医药学会青年委员会 副主任委员
Fitoterapia期刊副主编；J Pharm Anal期刊青年编委
代表论文
1. Zhilan Qian, Haishuang Yu, Chenglin Song, Yang Zhang, Qi Liu, Xudong Qu, Min Ye*, Xue Qiao*, Menghao Cai*. Biosynthesis of plant vitexin-derived flavonoid glycosides in yeast. Nat. Synth. 2026, 5, 335-348. (Cover)
2. Xue Qiao*, Alan Houghton, James Reed, Burkhard Steuernagel, Jiahe Zhang, Charlotte Owen, Aymeric Leveau, Anastasia Orme, Thomas Louveau, Rachel Melton, Brande B. H. Wulff, Anne Osbourn*. Comprehensive mutant chemotyping reveals embedding of a lineage-specific biosynthetic gene cluster in wider plant metabolism. Proc. Natl. Acad. Sci. U. S. A.2025, 122, e2417588122.
3. Chenglin Song#, Yuxi Huang#, Xiaolin Sa#, Linlin Wang, Mingju Yao, Zhengtong Jin, Yang Sun, Min Ye*, Xue Qiao*. Identification of Forsythoside A from Forsythia fruit for alleviating MAFLD via metabolic remodeling and IL-17 pathway regulation. J. Pharm. Anal. 2025, 15(12), 101321.
4. Mingju Yao#, Haotian Wang#, Zilong Wang, Chenglin Song, Xiaolin Sa, Wei Du, Min Ye, Xue Qiao*. Construct phenylethanoid glycosides harnessing biosynthetic networks, protein engineering and one-pot multienzyme cascades. Angew. Chem. Int. Ed. 2024, e202402546.
5. Linlin Wang#, Zhihui Jiang#, Jiahe Zhang#, Kuan Chen, Meng Zhang, Zilong Wang, Binju Wang*, Min Ye*, Xue Qiao*. Characterization and structure-based protein engineering of a regiospecific saponin acetyltransferase from Astragalus membranaceus. Nature Commun. 2023, 14, 5969.
6. Hao-Tian Wang#, Zi-Long Wang#, Kuan Chen, Ming-Ju Yao, Meng Zhang, Rong-Shen Wang, Jia-He Zhang, Hans Ågren, Fu-Dong Li, Junhao Li, Xue Qiao*, Min Ye*. Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants. Nature Commun., 2023, 14, 6658.
7. Kuan Chen#, Meng Zhang#, Baihan Gao#, Aobulikasimu Hasan, Junhao Li, Yang’oujie Bao, Jingjing Fan, Rong Yu, Yang Yi, Hans Agren, Zilong Wang, Haiyang Liu, Min Ye*, Xue Qiao*. Characterization and protein engineering of glycosyltransferases for the biosynthesis of diverse hepatoprotective cycloartane-type saponins in Astragalus membranaceus. Plant Biotechnol. J. 2023, 21, 698–710.
8. Meng Zhang, Yang Yi, Baihan Gao, Hui-Fei Su, Yang-Oujie Bao, Xiao-Meng Shi, Hai-Dong Wang, Fu-Dong Li, Min Ye*, Xue Qiao*. Functional characterization and protein engineering of a triterpene 3-/6-/2′-O-glycosyltransferase reveal a conserved residue critical for the regiospecificity. Angew. Chem. Int. Ed. 2022, 61(8), e202113587.
9. Meng Zhang#, Fu-Dong Li#, Kai Li#, Zi-Long Wang, Yu-Xi Wang, Jun-Bin He, Hui-Fei Su, Zhong-Yi Zhang, Chang-Biao Chi, Xiao-Meng Shi, Cai-Hong Yun, Zhi-Yong Zhang, Zhen-Ming Liu, Liang-Ren Zhang, Dong-Hui Yang, Ming Ma*, Xue Qiao*, Min Ye*. Functional characterization and structural basis of an efficient di-C-glycosyltransferase from Glycyrrhiza glabra. J. Am. Chem. Soc. 2020, 142, 3506-3512.
10. Jun-Bin He#, Peng Zhao#, Zhi-Min Hu, Shuang Liu, Yi Kuang, Meng Zhang, Bin Li, Cai-Hong Yun*, Xue Qiao*, Min Ye*. Molecular characterization and structural basis of a promiscuous C-glycosyltransferase from Trollius chinensis.Angew. Chem. Int. Ed. 2019, 58, 11513-11520.
